Pilot is the first episode of Life in Pieces, first aired on September 21, 2015.
- In "Story One: First Date", Matt (Thomas Sadoski) and Colleen (Angelique Cabral) return from their first date, but her ex-fiance Chad (Jordan Peele) is still living at her house, and Matt is living with his parents Joan (Dianne Wiest) and John (James Brolin), so they end up getting caught having sex in the car.
- In "Story Two: The Delivery", Jen's (Zoe Lister-Jones) vagina is ripped during childbirth and needs her husband Greg's (Colin Hanks) help in recovery.
- In "Story Three: The College Tour", Tim (Dan Bakkedahl) and Heather (Betsy Brandt) tour a college campus for their son Tyler (Niall Cunningham). In the hotel, their daughter Samantha (Holly J. Barrett) gets her first period and their younger daughter Sophia (Giselle Eisenberg) learns Santa is not real.
- In "Story Four: The Funeral", John celebrates his 70th birthday with a mock-funeral for himself. His children Matt, Greg and Heather participate with their families.
- Colin Hanks as Greg Short
- Betsy Brandt as Heather Hughes
- Thomas Sadoski as Matt Short
- Zoe Lister-Jones as Jen Short
- Dan Bakkedahl as Tim Hughes
- Angelique Cabral as Colleen Ortega
- Niall Cunningham as Tyler Hughes
- Holly J. Barrett as Samantha Hughes
- Giselle Eisenberg as Sophia Hughes
- James Brolin as John Short
- Dianne Wiest as Joan Short
- This is the first episode of Life in Pieces.
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